The limit of detection (LOD) and the limit of quantification (LOQ
) of the device were calculated from the calibration curve data.
Mercury concentrations above LOQ
were compared to occupational exposure reference values determined in national legislation and international organizations (Table 1).
EC and formaldehyde were not included in the Table, since these compounds were found at levels between the LOD and LOQ
of the method (0.4 and 1[micro]g [L.sup.-1], respectively, for both compounds) in all samples.
Linearity results, LOQ
, and LOD Compound [lambda] Equation [r.sup.2] Slope RSD % Galantamine 292 Y=118484.33X + 448.2 0.995 2.0594 Compound Intercept RSD % LOQ
LOD ([micro]g) ([micro]g) Galantamine 4.4493 25 7.5 LOQ
: Limit of quantification, LOD: Limit of detection, RSD: Relative standard deviation Table 3.
Least-squares linear regression parameters slope 0.017 0.022 0.02 0.03 intercept 0.011 0.12 0.007 0.101 Coefficient of correlation 0.99 0.98 0.99 0.98 LOD [ng/[ml.sup.-1]] 0.51 0.43 0.07 0.23 LOQ
ng/[ml.sup.-1] 1.58 1.29 0.14 0.71 ng/[wipe.sup.-1] 3.61 2.58 0.28 1.42 pg/[cm.sup.-2] 9.0 6.4 0.7 3.5 Within-session accuracy [%] 5.8 4.1 6.8 5.6 Repeatability [%] twithin-session 3.9 2.6 4.6 4.6 inter-session 6.7 5.9 6.5 4.9 Antiblastic drug IRT VNC VNB EPI Molecular weight [Da] 586.69 824.97 810.97 543.55 Precursor ion [m/z] 587.35 825.57 406.40 544.28 quantitative product 124.10 765.45 271.87 130.07 qualitative product 110.02 807.51 n.d.
LOD and LOQ
values in our study and literature were shown in Table-2.
The linearity graph also revealed that this electrode had sensitivity of 0.0008 mA/mM and both limit of detection (LOD) and limit of quantity (LOQ
) of 0.478 mM and 1.598 mM, respectively (Fig.
This Day 120 LoQ
were received by the company in November 2017and included Major Objections in areas including efficacy, safety (including hematological, cardiovascular and infectious toxicities) and other concerns including the size of the data set and the pharmacokinetic analyses of the two dosing regimens studied in PERSIST-2.
In present work LOD and LOQ
were calculated by using the signal-to-noise method.
The method for nicotine quantification from e-liquids was validated as per ICH Q2(R1) and USP <1225> guidelines for specificity, linearity, accuracy, precision, LOD, LOQ
, and robustness [20, 23].
The limit of detection (LOD) and limit of quantification (LOQ
) for each pesticide were also estimated from the analytical curves for each pesticide.
Limit of Detection (LOD) and Limit of Quantification (LOQ
) were analyzed based on the standard deviation (SD) of the response and the slope.