LQTLLean Quaternary Temporal Logic
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In patients with LQTl mutations, cardiac events tend to occur during states of increased physical or emotional stress; arrhythmia is classically triggered by exercise, swimming, or sudden emotion.
For example, in LQTl, a dominant-negative mutation (in which an abnormal gene product interferes with normal gene product's ability to function) conferred a twofold risk of cardiac events, compared with mutations causing haploinsufficiency of the protein (not enough protein produced for normal function).