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LQTSLong QT Syndrome
LQTSLaughs Quietly To Self
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References in periodicals archive ?
LQTS, arrhythmogenic right ventricular cardiomyopathy (ARVC) with Naxos syndrome) or X-linked (e.g.
Splawsik reported that the KCNE1 gene mutation relates to QT prolongation syndrome (LQTS) [31].
concluded that the QT interval and monophasic action potential durations were shortened only in the cilnidipine group, but such effects were not observed in the amlodipine group, using heart of canine chronic atrioventricular block model [26] (cardiac sudden death model) is known to have a ventricular electrical remodeling, which mimics the pathophysiology of LQTS. The effect of cilnidipine on QTc depression is more than amlodipine and was clearly analyzed in the present study.
LQTS and also other cardiovascular diseases are caused by different mutations either in the same gene or in different genes.
Heart rhythm disorder in LQTS can be caused by excessive physical activity, swimming, emotional stress, sound stimuli (e.g., alarm clock), etc.
Nowadays, polymedication is a given fact, leading to increased risk of iatrogenesis and making the differential diagnosis between acquired and congenital LQTS quite difficult.
Detecting or confirming the subtype of LQTS through genetic testing can also play a role in guiding therapy through lifestyle modifications and drug treatment.
Though the patient had no prior history of syncopal episodes, family history of sudden cardiac death, or LQTS, there is a possibility that the patient may have had undiagnosed LQTS and hypokalemia may have unmasked this, as the QT interval was still mildly prolonged at the time of discharge even after the correction of hypokalemia.
Another drug, thiopental, is reported to prolong the [QT.sub.c] interval; nevertheless, it reduces TDP and can therefore be used safely for anesthesia induction and maintenance in children with LQTS (5).
Recording of QTc intervals beyond the normal cut-off values should raise the suspicion of either acquired or congenital long QT syndrome (LQTS).
To the Editor.--Long QT syndrome (LQTS) is one of several inherited genetically heterogeneous cardiac channelopathies (CCs) that are the cause for as many as 35% of sudden unexplained cardiac death (SUD) cases (1) and 7% of cases of sudden infant death syndrome.
A prolonged QT interval may be the result of a primary long QT syndrome (LQTS) or an acquired condition from electrolyte imbalance, medication effect, or toxin exposure.