LR+

AcronymDefinition
LR+Positive Likelihood Ratio
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Abnormally high levels of TPOAb had an LR+ of 4.3 and LR- of 0.6 (P <.0001) for thyroid disease, compared with an LR+ of 3.4 and LR- of 0.7 (P <.01) for abnormally elevated thyroglobulin.
TABLE Autoimmune markers in thyroid disorders % TRAb % TRAb % OF >3.4 U/L >10 U/L STUDY PATIENTS LR+ LR- LR+ LR- Graves' disease 68 4.6 0.1 13.0 0.2 CAHT 20 0.2 4.7 0.1 2.8 Subacute 4 0.2 3.0 0.0 2.4 thyroiditis Thyroid nodules 6 0.2 3.4 0.0 2.4 Others 2 0.8 1.4 0.0 2.3 % AMA % THYROGLOBULIN POSITIVE POSITIVE LR+ LR- LR+ LR- Graves' disease 1.3 0.6 1.1 0.9 CAHT 1.4 0.2 1.4 0.6 Subacute 0.1 3.6 0.5 1.5 thyroiditis Thyroid nodules 0.1 4.1 0.1 2.0 Others 0.0 2.8 0 2.0 AMA, antimicrosomal antibodies; CAHT, chronic autoimmune (Hashimoto's) thyroiditis; LR+, positive likelihood ratio; LR-, negative likelihood ratio; TRAb, thyrotropin receptor antibodies Source: Khoo DHC, et al.
How useful are autoantibodies in diagnosing thyroid disorders?
The LR+ and LR- for FSH, which are of mid-high magnitude, would suggest it to be the best single diagnostic test.
What is the best way to diagnose menopause?
In a systematic review of 4 studies, hysteroscopy had a pooled LR+ of 29.4 for diagnosing fibroids.
What is the appropriate diagnostic evaluation of fibroids?
* OUTCOMES MEASURED The sensitivity, specificity, LR+, and LR- were calculated for examination of anterior cruciate ligament (ACL) injuries ("composite" examination and Lachman, anterior drawer, and lateral pivot shift maneuvers), posterior cruciate ligament (PCL) injuries ("general" examination and posterior drawer and abduction stress test maneuvers), and for meniscus injuries (joint line tenderness, presence of joint effusion, and the McMurray and medial-lateral grind tests).
Summary IRs with 95% confidence intervals (95% CI) for examinations of ACL injuries were as follows: composite examination (specific maneuvers not delineated): LR+ = 25.0 (95% CI, 2.1-306.2), LR- = 0.04 (95% CI, 0.01-0.48); the Lachman test: LR+ = 25.0 05% CI, 2.7 - 651), LR - = 0.1 (95% CI, 0.0 - 0.4); anterior drawer test: LR+ = 3.8 (95% CI, 0.7 - 22.0), LR- = 0.3 (95% CI, 0.05 - 1.50); and pivot shift stress test: LR+ = 42 (95% CI, 2.7 - 651.0) and LR- = 0.1 (95% CI, 0.0-0.4).
For PCL examination: composite examination (specific maneuvers not delineated), LR+ = 21.0 (95% CI, 2.1-205.0) and LR- = 0.05 (95% CI, 0.01-0.50).
What is the diagnostic accuracy of the clinical examination for meniscus or ligamentous knee injuries? (Patient-Oriented Evidence that Matters)
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