Moreover, the correlation coefficients of blood pressure with LRAT, 25(OH)D, and VDR were analyzed by correlation analysis.
The expression level of LRAT in the hypertensive group was significantly lower than that in the control group (Figure 1(d)).
The association of LRAT and VDR with BP was analyzed in multivariable logistic regression model in Table 2, and the covariates of Z-score of BMI, breastfed, WC, HDL-C, LDL-C, LRAT, VDR, nuts, mushrooms, and algae food were included.
(A) Vitamin A and its precursors ([beta]-carotene) obtained from diet are absorbed by intestinal epithelium cells and esterified in retinyl esters by the enzyme lecithin retinol acyltransferase (LRAT
The single-course treatment data with QLT091001 is said to represent the first stage of dose regimen testing as the basis for a longer term multiple course regimen in RP due to mutations in RPE65 and LRAT
Additionally, the company's QLT091001 will be used for the treatment of autosomal recessive Retinitis Pigmentosa (RP) due to inherited mutations in LRAT
and RPE65 genes.
By current epidemiological estimates, there are at least 300,000 patients with RP worldwide, of which less than 5% carry the inherited deficiencies of either RPE65 or LRAT.
QLT091001 has received orphan drug designations for the treatment of the LRAT and RPE65 genetic mutations in both LCA and RP by the U.S.
These experiments used mice that have mutations in either the Rpe65 or Lrat
genes, the same as those associated with approximately 10% of LCA in humans.
The presence of toxic heavy metals in the Arctic is evidence of long-range atmospheric transport (LRAT) of emissions from industrial and urban areas in temperate regions.
LRAT has moved atmospheric industrial emissions of these metals around the world for more than a century.
and Canadian industrial and urban Pb via LRAT since the 1800s (Outridge et al.