LRC-CPPTLipid Research Clinics Study Coronary Primary Prevention Trial
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The LRC Coronary Primary Prevention Trial (LRC-CPPT) was begun in 1974 with the goal of recruiting 3600 men between the ages of 35 and 59 years whose baseline LDL-cholesterol was >190 mg/dL.
Since 1984, the Lipids Research Clinics Coronary Primary Prevention Trial (LRC-CPPT) established coronary heart disease as more common in the United States than in some other countries.
The 7-year Lipid Research Clinics Coronary Prevention Trial (LRC-CPPT) documented a reduction in CHD death and/or nonfatal MI (NNT = 59) with a 12.6% reduction in LDL-C with the use of cholestyramine, a bile acid resin, 24 g per day.