Based on the structure (9) and domain information of the LHCGR wild-type protein obtained from Uniprot (http://www.uniprot.org/), the amino acid substitution at the 11 7th position (p.Gly117Arg) was predicted to disrupt the first LRR
domain, which may affect recognition and binding affinity of LHCGR to hCG and/or other ligands.
Most of the R-genes are found with a nucleotide binding site domains (NBS) 8 and leucine rich repeats (LRR
) at the C-terminal and with either a toll-interleukin-1-receptor (TIR) domain or putative coiled coil domain at the N-terminal.
Following mastectomy for operable breast cancer, approximately 5-20 percent of patients will develop a locoregional recurrence (LRR
) with or without concomitant distant metastasis (DM) within 10 years [1, 2].
TLRs 7 and 8 have 26 LRR
motifs in their extracellular domain, which contain multiple insertions such as the Z-loop or undefined region situated between LRRs
14 and 15 (Figures 1(e) and 1(f)) .
TLRs are pattern-recognition receptors (PRR) that have an extracellular leucine-rich repeat (LRR
) domain as well as an intracellular toll/Interleukin-1 receptor (TIR) domain (Fig.
It was also found that protein sequence of LRR
regions related to biotic stresses showed homology to other blast genes (Pib, Pi-kh, Pi-zt and Pi-9) located at different chromosomes.
TLRs are type 1 transmembrane proteins with an extracellular domain with leucine-rich repeats (LRRs
) and a cytoplasmic Toll/IL-1 receptor domain .
Since 2001, ORS has been developing its Low Riser Return System (LRRS
) technology providing managed pressure drilling for the subsea sector.Country: NorwaySector: Petroleum/Natural Gas/Coal, ElectronicsTarget: Ocean Riser Systems AS (ORS)Buyer: AGR Group ASAType: Corporate acquisitionFinancing: All-stockStatus: Closed
In the present study also changes appeared to be concentrated in the extracellular region of TLR4, particularly in the E3P1 region of LRRs
. Changes like this, responsible for ligand binding have recently been reported (Jin et al., 2007).
TLRs have an ectodomain or extracellular domain with leucine-rich repeats (LRRs
), a transmembrane region and a cytoplasmic domain, homologous to the interleukin-1 (IL-1) receptor, known as Toll/IL-1R (TIR) (3).
About 40% of LRRs
were seen concurrently or after the development of distant metastases.
Most of the polymerizations that have been reported being followed by Raman spectroscopy used expensive high-resolution Raman spectrophotometers; however, portable, low-cost, low-resolution Raman spectrometers (LRRS
) are now available, which can be used to follow heterogeneous polymerizations on line (9).