BRAHMS PCT assay provides information on the presence and severity of bacterial infection, helping physicians in emergency departments, intensive care and other hospital units decide whether to initiate antibiotic therapy in patients with suspected or confirmed lower respiratory tract infections (LRTI
) and when to safely discontinue antibiotics in patients with LRTI
was the most common reason for the treatment in pediatric and neonatal wards.
It is based on the primary analysis of the phase IIb trial to evaluate the safety and efficacy of MEDI8897, which met its primary endpoint defined as a statistically-significant reduction in the incidence of medically-attended LRTI
caused by reverse transcriptase polymerase chain reaction-confirmed RSV for 150 days after dosing in healthy preterm infants.
This BTD is based on the primary analysis of the phase IIb trial to evaluate the safety and efficacy of MEDI8897, which met its primary endpoint defined as a statistically-significant reduction in the incidence of medically-attended LRTI
caused by reverse transcriptase polymerase chain reaction-confirmed RSV, for 150 days after dosing in healthy preterm infants.
Sobi will also have the right to participate in payments from the US profits or losses for potential new medicine MEDI8897 in development for RSV-induced LRTI
. AstraZeneca will continue to develop MEDI8897 in collaboration with Sanofi Pasteur, the vaccines division of Sanofi SA.
MEDI8897 is a single dose extended half-life anti-RSV F being developed for the prevention of LRTI
caused by RSV in all infants entering their first RSV season and children with chronic lung disease or congenital heart disease entering their first and second RSV season.
In 1981, Thomson (18) began performing a novel technique of LRTI
using the abductor pollicis longus (APL) tendon rather than the FCR tendon.
The charts of infants admitted to KEH with a diagnosis of LRTI
between 1 January 2015 and 31 December 2015 were reviewed.* The WHO definition of LRTI
used refers to an outcome definition incorporating at least one specific LRTI
sign, reported by a caregiver or the study personnel (fast or difficult breathing, chest wall indrawing) and/or abnormal auscultatory findings (crackles/ crepitations or bronchial breath sounds).
Human coronaviruses (HCoVs) OC43, 229E, NL63, and HKU1 are frequently associated with upper respiratory tract infection but can also cause lower respiratory tract infections (LRTIs
), such as pneumonia or bronchitis.
In our study, we observed that PCT and other inflammatory marker levels were higher in the patients with LRTI
than in noninfectious cases.
(2010) found that each log-unit higher maternal serum DDE concentrations during the first trimester of pregnancy was associated with a 25% higher risk of LRTIs
in 14month-old offspring [RR = 1.25 (95% CI: 1.01, 1.55)].
(15) in Turkey, the prevalence of RSV was found as 37.9% in 671 patients aged below 24 months who were hospitalized because of LRTI
; babies aged between 0 and three months constituted 38.3% of these patients.