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The mean age of patients with LSIL was 25.8[+ or -]15.2 years.
Reich and Regaueds hypothesis is not so different from ours.1 We also believe that low-grade squamous intraepithelial lesion (LSIL)/condyloma arises from original squamous epithelium of the exocervix or mature squamous metaplasia that arises from the columnar cells in the transformation zone and goes through the process of reserve cell proliferation, immature metaplasia, and then maturation (mature metaplasia).
According to the morphology determined in bioptic samples, cervical findings were characterized as normal findings (non-specific cervicitis); LSIL (cervicitis chronica virosa, flat condyloma, mild dysplasia); HSIL (moderate dysplasia, severe dysplasia, in situ squamous cell carcinoma) and invasive squamous cell carcinoma .
MGMT methylation frequency decreased significantly in CIN2+ subgroup of ASCUS ( P = 0.010), and C13ORF18 methylation frequency increased significantly in CIN2+ subgroup of low-grade squamous intraepithelial lesion (LSIL) ( ?
The cytological diagnosis from the 325 sexually active women (average age 37 years; range 14-79 years), included 313 (96.3%) women with NILM and 11 (3.4%) with some cytological abnormality as follows: 4 ASCUS, 4 LSIL, 3 ASC-H.
Among the HSIL, only 14.29% were positive for p53 overexpression [Figure 2a] while among the LSIL not a single case was positive for p53 overexpression [Figure 2b].
Guidelines also recommend colposcopy for WLWH with ASCUS who test positive for HPV, low-grade squamous epithelial lesion (LSIL), ASCUS-cannot rule out high grade (ASC-H), or high-grade squamous epithelial lesion (HSIL) [6, 9].
The cutoff values for LSIL and HSIL were [greater than or equal to] 3 and [greater than or equal to] 5, respectively [1, 19-21].
Among men with HIV, 15% with a lower-grade abnormality (ASCUS or LSIL) on their first test had a higher-grade abnormality (for example, ASCUS [right arrow] LSIL or LSIL [right arrow] ASC-H or HSIL) on their second test.
If LSIL (CIN1) is noted on biopsy, reevaluation post partum should be strongly considered, unless a suspicious lesion was felt to be inadequately biopsied.
Seventeen (5.7%) women presented cells alterations, fourteen (4.7%) of them only with atypical cells, one (0.3%) with LSIL and two (0.7%) with HSIL.
The remaining 11(6.9%) with pre cancer minimal abnormal (LSIL) CIN-1 presented.
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- LSI Logic Corporation
- LSI-11 bus
- LSI11 bus