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As SLE is more common in women of reproductive age, the time from onset of symptoms to diagnosis in pediatric, male patients with LSLE is longer than that in patients with adult-onset SLE (ASLE) [10, 11].
Age at onset was considered ASLE if it was <50 years and LSLE if it was [greater than or equal to] 50 years, as this is the most commonly used cut-off age in most protocols [14-17].
Overall, 41 (56.9%) patients had ASLE, and 31 (43.05%) patients had LSLE based on the age at disease onset.
Of the concomitant comorbid diseases, while thyroid disease, HT, and CAD were more common in LSLE (p=0.025, 0.019, and 0.018, respectively), no difference was found with regard to the other comorbid diseases, such as COPD, asthma, APS, and DM (Table 3).
Age at onset older than 50 years is rare in SLE, and this is called LSLE. In our study the percentage of late-onset lupus was found to be 43.05%, which is higher than in the literature (12.4% in Korean patients, 4.76% in British patients, 15.05% in Brazilian patients, and 6.9% in Latin American patients) [17, 19-21].
The ratio of F/M patients was 8:1 and was 12.6:1 in ASLE and 5.2:1 in LSLE. These findings are consistent with the literature, and the decrease in this ratio among genders as patients become older supports the finding that estrogen plays a role in pathogenesis [22, 23].
The most commonly accepted opinion is that LSLE has a stealthier and milder route.
Mucocutaneous findings, such as malar rash, photosensitivity, oral ulcers, and Raynaud's phenomenon, are more common in ASLE in Latin America, only malar rash is more common in JSLE and ASLE than in LSLE in Brazil, and only oral ulcers are more common in JSLE and ASLE in Korea [17, 19, 21].
It is known that although the disease has a more benign course in LSLE, organ damage and mortality are higher in the study by Catoggio et al.
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- LSM1 homolog, U6 small nuclear RNA associated
- LSM10, U7 small nuclear RNA associated
- LSM11 homolog, U7 small nuclear RNA associated
- LSM11, U7 small nuclear RNA associated