LSP1Leukocyte-Specific Protein 1
LSP1Larval Serum Protein 1 (genetics)
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Future research will reveal if failure to regulate actin cytoskeleton dynamics for vesicle trafficking is a common feature in neutropenias caused by mutations in actin-regulating proteins such as Rac2, WASp, LSP1 in NAD 74/89, or in actin itself as in [beta]actin deficiency.
Abbreviations BRWS: Baraitser-Winter syndrome CGD: Chronic granulomatous disease CHS: Chediak-Higashi syndrome CMT: Charcot-Marie-Tooth disease CTSC: Cathepsin C fMLP: Formyl-methionyl-leucyl-phenylalanine GCSF: Granulocyte colony-stimulating factor ICAM: Intercellular adhesion molecule LAD: Leukocyte adhesion deficiency LSP1: Lymphocyte-specific protein 1 MTOC: Microtubule organizing center NAD: Neutrophil actin dysfunction NE: Neutrophil elastase PLS: Papillon-Lefevre syndrome SCN: Severe congenital neutropenia SDS: Shwachman-Diamond syndrome WAVE: WASp-family verprolin-homologous protein WAS: Wiskott-Aldrich syndrome WASp: WAS protein WHIM: Warts, hypogammaglobulinemia, infections, myelokathexis XLN: X-linked neutropenia.
Wang et al., "LSP1 modulates leukocyte populations in resting and inflamed peritoneum," Blood, vol.
Kaur et al., "LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration," Journal of Experimental Medicine, vol.
Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.
Breast cancer risk Genes References Rare high-risk genes BRC A1 [1] (x 10-20 lifetime risk) BRC A2 [2] TP53 [4] Rare moderate-risk genes ATM [6] (x 2-4 lifetime risk) BRIP1 [8] CHEK2 [7] PALB2 [9,10] Common low-risk genes FGFR2 [15,18] (x <2 lifetime risk) MAP3K1 [15] TNCR9 [15] LSP1 [15] CASP8* [12] Variants in genes [15,19-21] at chromosomes 6q22.33, 2q35, 16q12 and 5p12 * CASP8 variant is protective.