Future research will reveal if failure to regulate actin cytoskeleton dynamics for vesicle trafficking is a common feature in neutropenias caused by mutations in actin-regulating proteins such as Rac2, WASp, LSP1 in NAD 74/89, or in actin itself as in [beta]actin deficiency.
Abbreviations BRWS: Baraitser-Winter syndrome CGD: Chronic granulomatous disease CHS: Chediak-Higashi syndrome CMT: Charcot-Marie-Tooth disease CTSC: Cathepsin C fMLP: Formyl-methionyl-leucyl-phenylalanine GCSF: Granulocyte colony-stimulating factor ICAM: Intercellular adhesion molecule LAD: Leukocyte adhesion deficiency LSP1: Lymphocyte-specific protein 1 MTOC: Microtubule organizing center NAD: Neutrophil actin dysfunction NE: Neutrophil elastase PLS: Papillon-Lefevre syndrome SCN: Severe congenital neutropenia SDS: Shwachman-Diamond syndrome WAVE: WASp-family verprolin-homologous protein WAS: Wiskott-Aldrich syndrome WASp: WAS protein WHIM: Warts, hypogammaglobulinemia, infections, myelokathexis XLN: X-linked neutropenia.
Wang et al., "LSP1 modulates leukocyte populations in resting and inflamed peritoneum," Blood, vol.
Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.
Breast cancer risk Genes References Rare high-risk genes BRC A1  (x 10-20 lifetime risk) BRC A2  TP53  Rare moderate-risk genes ATM  (x 2-4 lifetime risk) BRIP1  CHEK2  PALB2 [9,10] Common low-risk genes FGFR2 [15,18] (x <2 lifetime risk) MAP3K1  TNCR9  LSP1  CASP8*  Variants in genes [15,19-21] at chromosomes 6q22.33, 2q35, 16q12 and 5p12 * CASP8 variant is protective.