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Human MCs produce lipid mediators such as PGD2 and LTD4 following FceRI activation [31, 94-96].
The concentration of LTD4, IL-6, ACP increased significantly.
PTZ was purchased from Sigma-Aldrich (USA), LTD4 and montelukast were from Cayman Chemical (USA), and phenobarbital was from Cristalia Pharmaceutical Co.
Since LTs are important inflammatory mediators in gouty arthritis (15 Rae) and drugs such as montelukast (Mk) act as a competitive inhibitor of LTs by joining selectively to LT receptors (16), especially to the LTD4 receptor, we sought to investigate the effect of montelukast in a model of experimental arthritis induced by SMU crystals deposits in the air pouch model in BALB/c mice (17).
Influences of gender and maturation on responses of guinea-pig airway tissues to LTD4. Eur J Pharmacol 112:423-427.
(1) At this receptor, Singulair inhibits the physiologic action of LTD4, a leukotriene released by various inflammatory cells that normally initiates the symptoms of asthma.
The scenarios of Ltd4 and Ltd5 were the fourth and the fifth, respectively, by various methods.
The products of the 5-1ipoxygenase pathway include the leukotrienes LTC4, LTD4, and LTE4, which are potent inflammatory mediators that can act to (1) induce mucus secretion, bronchoconstriction of the airway, and edema of the nasal mucosa and (2) attract eosinophils into the airways.
Leukotrienes LTA4, LTB4, LTC4, LTD4 and LTE4 are metabolized at different levels via the 5-1ipoxygenase pathway in response to certain antigens causing bronchoconstriction, increased mucous production, and inflammation (Bisgaard, 2001; Coffey & Peters-Golden, 2003; Krawiec & Wenzel, 1999; Lasley, 2003).
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- LTD4 receptor antagonists