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LVEDPLeft Ventricular End-Diastolic Pressure
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As shown in Figure 1, 16-week MIE did not lead to changes of heart weight/body weight (HW/BW) ratio and indexes of cardiac function including LVSP, LVEDP, + [LVdP/dt.sub.max], and - [LVdP/dt.sub.max] in WKY rats, indicating MIE does not affect cardiac function in non-hypertensive rats.
During ischemia, increased myocardial stiffness in addition to a decreased rate of wall thinning and slow active pressure decay contributes to the upward shift in the LV-wall thickness and pressure-volume relationships which lead to an increased susceptibility to LVEDP. [15, 17]
To assess the effect of PRE-084 on cardiac function, hemodynamic parameters such as LVEDP, LVSP, and LV [+ or -] dp/dt were measured.
To test the hypothesis that chronic stress can induce changes in the left ventricular hemodynamics in an animal model of CUS and whether quercetin is able to block these changes, we inserted a pressure catheter directly into the LV to measure LV systolic pressure (LVSP), LV end diastolic pressure (LVEDP), maximal rate of rise in LV pressure (+dP/dt), and maximal rate of decline in LV pressure (-dP/dt).
However, I/R injury was found to increase LVEDP (Figure 1(d)) in the I/R group (P < 0.01).
As shown in Figure 5, PR39-ADM significantly increased LVSP and LV [+ or -] dP/dt max and dramatically decreased LVEDP (compared to that in the other MI groups, P < 0.05).
Compared to groups A and B, LVESP and LV [+ or -] dp/[dt.sub.max] markedly decreased; LVEDP markedly increased (P < 0.05 or P < 0.01) in groups C, D, E, and F.
ISO administration caused elevation in left ventricular end diastolic pressure (LVEDP) and decline in [+ or -] LVdP/[dt.sub.max] (P < 0.001).
The volume of the balloon was adjusted using the BIOPAC system (BIOPAC Systems Inc., Goleta, CA, USA) to provide and sustain a left ventricular end-diastolic pressure (LVEDP) of 5 to 10 mmHg from the beginning of the experiment.
Abbreviations: EKG: Electrocardiogram, ECHO: Echocardiogram, CT: Computed tomography, LVEDP: Left ventricular end diastolic pressure
(24) Some authors have argued that a significant dilatation of the LV, commencing immediately after coronary occlusion in rats, can produce an increase in LVEDP and a diminished slope of LV pressure versus time.