In the CLEOPATRA trial, the cardiac safety analysis part did not show an increase in the incidence of LVSD
when dual anti-HER2 therapy was used .
A clustering analysis was performed, considering the assessed cardiac functional parameters (LVEF, LVFS, LVSD
, LVDD, LVSV, and LVDV), in order to identify sample groups in an unsupervised fashion.
We compared baseline characteristics between COPD subjects with preserved LVEF and LVSD
. Data are presented as median and interquartile range (IQR) and as whole numbers and percentages.
Sham AoS P HR (bpm) 305 [+ or -] 34 296 [+ or -] 32 0.288 LVDD (mm) 7.67 [+ or -] 0.56 7.86 [+ or -] 0.78 0.266 LVSD
(mm) 3.58 [+ or -] 0.42 3.41 [+ or -] 1.18 0.458 RWT 0.35 [+ or -] 0.07 0.44 [+ or -] 0.10 < 0.001 LA/AO 1.46 [+ or -] 0.17 1.83 [+ or -] 0.42 < 0.001 EF (%) 0.90 [+ or -] 0.03 0.90 [+ or -] 0.10 0.773 FS (%) 29.8 [+ or -] 3.0 31.9 [+ or -] 10.0 0.268 E (cm/s) 86.9 [+ or -] 9.0 110 [+ or -] 29 < 0.001 A (cm/s) 59.6 [+ or -] 16.1 62.7 [+ or -] 25.7 0.56 E/A 1.52 [+ or -] 0.28 2.42 [+ or -] 1.54 0.025 Data are reported as means [+ or -] SD.
The severity of the LVSD
was measured according to the left ventricular ejection fraction (LVEF) and the Teichhoolz method was applied following the II Brazilian Guideline for Severe Heart Diseases .
This graph shows the rising trend of the moderate-tosevere LVSD
curve across the stroke severity group; 15 patients (62.5%) fall in the severe stroke group.
The new VINDICATE study randomized 223 patients with CHF due to LVSD
and vitamin D deficiency to 1 year's treatment with 4,000 IU of 25(OH) vitamin D3 daily, or placebo, Dr.
Doses of 200 to 300 mg/d used over 8 to 12 weeks in DM2 patients on statin drugs and in patients with ischemic left ventricular systolic dysfunction (LVSD
) have shown significant improvements in FMD.
Transthoracic echocardiograms and assessment of interventricular septum (IVS) and left ventricular posterior wall (LVPW) diastolic thickness, left ventricular end-diastolic and endsystolic diameter (LVDD, LVSD
), and fractional shortening (FS) were performed as described previously .
The aim of this study was to investigate whether co-enzyme Q10 (CoQ) supplementation, which is an obligatory coenzyme in the mitochondrial respiratory transport chain, can reverse MD and improve endothelial function in patients with ischaemic left ventricular systolic dysfunction (LVSD
Left Ventricular Systolic Dysfunction (LVSD
) was defined as an Ejection Fraction (EF) less than 50% and Left Ventricular Diastolic Dysfunction (LVDD) was defined as an EF greater than 50% in the presence of left ventricular hypertrophy with an abnormal mitral inflow pattern.
In patients presenting with acute coronary syndrome (ACS), (9) increased markers of neurohormonal activation, including serum aldosterone, are associated with early and late adverse cardiovascular events, such as heart failure, arrhythmia, and mortality (1-3).An association between serum aldosterone and outcomes has been observed across the spectrum of patients with ACS, with and without left ventricular systolic dysfunction (LVSD