As shown in Figure 1, 16-week MIE did not lead to changes of heart weight/body weight (HW/BW) ratio and indexes of cardiac function including LVSP
, LVEDP, + [LVdP/dt.sub.max], and - [LVdP/dt.sub.max] in WKY rats, indicating MIE does not affect cardiac function in non-hypertensive rats.
To assess the effect of PRE-084 on cardiac function, hemodynamic parameters such as LVEDP, LVSP
, and LV [+ or -] dp/dt were measured.
After treatment with a low or high dose of fenofibrate for 28 days, rats subjected to AAC showedweakened hypertrophyin the left ventricle supported by decreased HW/BW, LVW/BW, LVAW, LVPW, and mRNA levels of hypertrophic genes (ANP and BNP), although treatment with fenofibrate caused no significant change in LVSP
(Figure 1 and Table 1).
Here, our study shows that LVSP
, LVEDP, and HR decreased in the sHT rat group, and negative correlations were found between TSH and this index, with the present study .
To test the hypothesis that chronic stress can induce changes in the left ventricular hemodynamics in an animal model of CUS and whether quercetin is able to block these changes, we inserted a pressure catheter directly into the LV to measure LV systolic pressure (LVSP
), LV end diastolic pressure (LVEDP), maximal rate of rise in LV pressure (+dP/dt), and maximal rate of decline in LV pressure (-dP/dt).
As shown in Figure 1, I/R injury was found to greatly decrease FS (Figure 1(a)), EF (Figure 1(b)), and LVSP
TSA treatment significantly increased +dp/df, -dp/df, and LVSP
after 3h of reperfusion (DIR versus DIR+TSA, p < 0.05).
As shown in Figure 5, PR39-ADM significantly increased LVSP
and LV [+ or -] dP/dt max and dramatically decreased LVEDP (compared to that in the other MI groups, P < 0.05).
and +dP/dt.max are important indexes for evaluating left ventricular systolic function.
low cordon with vertical shoot positioning (LVSP
), and vine spacing as the subplot (6 feet vs.
The left ventricular developed pressure (LVDP) and the left ventricular systolic pressure (LVSP
) increased significantly in the H+RD group compared to the CTL and RD groups (P < 0.05 and P < 0.0001, resp.) and in the H+QI groups (P < 0.01 versus QI groups).
Hemodynamic parameters including left ventricular systolic pressure (LVSP
), left ventricular end-diastolic pressure (LVEDP), and maximum rate of left ventricular pressure rise and fall (+dp/dtmax and--dp/dtmax) were significantly restored back to normal levels in AL-treated (8 mg/kg and 16 mg/kg) rats compared with diabetic model rats.