LWDHLake of the Woods District Hospital (Canada)
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Liuwei dihuang (LWDH) is a Chinese medicinal formula composed of dihuang (Rehmannia glutinosa), shanyao (Dioscorea opposite), shanzhuyu (Cornus officinalis), zexie (Alisma orientalis), hoelen (Poria cocos) and mudanpi (Paeonia suffruticosa).
In this study, we investigated the protective effects and mechanisms of the water extract of LWDH (LWDH-WE) in experimental models of PD using [MPP.sup.+]-treated primary mesencephalic neuronal cultures and MPTP-treated mice.
In addition, a rich collection of mutants has been used to explore the molecular mechanisms of the therapeutic components of TCM pharmacopeia, such as Liuwei Dihuang (LWDH) and Aiweixin [21, 22].