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Zhu et al., "Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXRa and PPAR[alpha] transcriptional programs," Endocrine Journal, vol.
Ou et al., "Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRa and LXR[beta]," Genes & Development, vol.
He brings considerable experience to the subject through his u- of desktop publishing for two newsletters he edits: LXRA Newsletter and Information Standards Quarterly.
Hylemon, "Lxra is the dominant regulator of CYP7A1 transcription," Biochemical and Biophysical Research Communications, vol.
Bouhlel et al., "Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPAR[gamma] and LXRa pathways," Circulation Research, vol.
Liver X receptors (LXRs) are nuclear receptors (NR) that belong to the family of ligand-activated transcription factors; there are two isoforms, LXRa and LXR[beta].
Steers also had lower hepatic mRNA levels of hepatic LXRa. The LXRs are nuclear receptors that are activated by endogenous oxysterols, oxidized derivatives of cholesterol (Edwards et al., 2002).
Liver X receptor alpha (LXRa) is a nuclear receptor that play a crucial role in regulating the expression of genes involve in lipid metabolism.
LXRa is detected at high levels in metabolic organs such as liver, adipose tissues, kidney, intestine, and spleen ; in contrast, LXR[beta] is ubiquitously expressed, the basis for an original name as "ubiquitous receptor" .
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