Late-onset hypogonadism was defined according to the previous accepted biochemical criteria (fasting levels of serum total testosterone < 2.31ng/mL or, in case of total testosterone between 2.31 and 3.46 ng/mL, calculated free testosterone < 65 pg/mL) together with signs and symptoms consistent with hypogonadism [12, 13].
Swerdloff et al., "Investigation treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations," European Journal of Endocrinology, vol.
Late-onset hypogonadism: Current concepts and controversies of pathogenesis, diagnosis and treatment.
Mortality associated to late-onset hypogonadism: Reasons not to treat with testosterone?
(25.) Tajar A, Huhtaniemi IT, O'Neill WT, et al Characteristics of Androgen Deficiency in Late-Onset Hypogonadism
: Results from the European Male Aging Study IEMAS).
Petchthong, "Effects of 8 year treatment of long-acting testosterone undecanoate on metabolic parameters, urinary symptoms, bone mineral density, and sexual function in men with late-onset hypogonadism
," The Journal of Sexual Medicine, vol.
Investigation, treatment and monitoring of late-onset hypogonadism
in males: ISA, ISSAM, EAU, EAA and ASA recommendations.
"Our findings have for the first time identified the key symptoms of late-onset hypogonadism
and suggest that testosterone treatment may only be useful in a relatively small number of cases where androgen deficiency is suspected, since many candidate symptoms of classic hypogonadism were not associated with decreased testosterone levels in older men," Wu added.
Inclusion criteria were (1) absence of important systemic diseases, both previous and ongoing, apart from late-onset hypogonadism
or type 2 diabetes mellitus; (2) availability of all the considered clinical, biochemical, and genetic parameters; (3) sexual relationship since at least 1 year before the visit; and (4) absence of previous investigation or treatment for sexual dysfunction.
This syndrome is also variably referred to as hypogonadism or late-onset hypogonadism
Beynon et al., "Identification of late-onset hypogonadism
in middle-aged and elderly men," The New England Journal of Medicine, vol.
Francomano et al., "Effects of long-acting testosterone undecanoate on bone mineral density in middle-aged men with late-onset hypogonadism
and metabolic syndrome: results from a 36 months controlled study," The Aging Male, vol.