LMDP

(redirected from Leiden Muscular Dystrophy Pages)
AcronymDefinition
LMDPLife-Cycle Mission Data Plan (US DoD)
LMDPLunar and Meteorite Disk Program (US NASA)
LMDPLeadership and Management Development Program (various locations)
LMDPLeiden Muscular Dystrophy Pages (Center for Human and Clinical Genetics, Leiden University Medical Center)
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References in periodicals archive ?
The DYSF geneis located on chromosome 2p13, which spans a genomic region of more than 230 kbp and comprises 55 exons.[sup][1],[2] It encodes a transmembrane protein DYSF which has been linked to membrane repair,[sup][14] Ca [sup]2+ signaling,[sup][15] cell adhesion,[sup][16] and angiogenesis.[sup][17] To date, 510 different mutations in this gene have been reported in the Leiden muscular dystrophy database worldwide (Leiden Muscular Dystrophy pages [c] www.dmd.nl).
The mutations found in patients were determined to be disease-causing by the following criteria: (1) mutations reported in literature, in the HGMD database, Leiden Muscular Dystrophy pages database (www.dmd.nl), or the UMD-DYSF mutations database (www.umd.be/DYSF); (2) novel null mutations, including nonsense mutations, frameshift mutations, canonical [+ or -]1 or 2 splice sites, and single exon or multiexon deletions; (3) novel missense mutations predicted to be disease-causing by a combination of four predictive software programs, including UMD-predictor (predicted as pathogenic/probably pathogenic),[sup][26] Mutation Taster (predicted as disease-causing),[sup][27] PolyPhen-2 (predicted as probably/possibly damaging),[sup][28] and SIFT software (J.
3) had previously been recorded in the Leiden Open Variation Database (LOVD), Leiden muscular dystrophy pages (http: //www.dmd.nl).