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LTB4Leukotriene B4
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References in periodicals archive ?
Peters-Golden, "Leukotriene B4 amplifies NF-[kappa]B activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression," Journal of Clinical Investigation, vol.
Authors stated previous research that "Prostaglandin E2 is involved in the classic signs of inflammation and possesses both pro-inflammatory and anti-inflammatory actions; thromboxane A2, formed by platelets, macrophages and polymorphonuclear leukocytes, can induce vasoconstriction and promotes aggregation of platelets as well as adhesiveness of polymorphonuclear neutrophils; leukotriene B4 (LTB4) can not only increase vascular permeability and enhance local blood flow by stimulating neutrophil secretion, but also stimulate other inflammatory substances."
Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis: the role of leukotriene B4. Eur.
Target: exclusive license to technology for targeting effects of leukotriene B4 (LTB4)
In addition to its health benefits, fish oils "can reduce levels of leukotriene B4, an inflammatory substance that has been linked with eczema.
Omega-6 fatty acids are commonly thought to be pro-inflammatory, because linoleic acid (the major omega-3 fatty acid in the diet) is converted in part to arachidonic acid, which is a precursor for pro-inflammatory eicosanoids such as prostaglandin E2, leukotriene B4, and thromboxane A2.
[3] When the human diet consist of high EPA, as well as, docosahexaenoic acid (DEA), both omega-3 fatty acids, there is a decrease in pro-inflammatory eicosanoids, prostaglandin E2 and leukotriene B4. These substances, which are derived from the AA and have been associated with inflammatory processes.[4]
Another important mediator to develop inflammation in RA is leukotriene B4 ([LTB.sub.4]) having strong attraction to neutrophils [38].
The production of these lipid mediators can be affected by inhaled materials; for instance, tobacco smoke has been shown to inhibit the production of leukotriene B4 by human alveolar macrophages [27].
These neutrophils secrete a lipid called leukotriene B4 that calls in more neutrophils, and more importantly, potent immune T cells that are the hallmark of eczema.