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LTC4SLeukotriene C4 Synthase
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Abbreviations SPMs: Specialized proresolving lipid mediators DHA: Docosahexaenoic acid PMNs: Polymorphonuclear leukocytes Ri: Resolution interval EPA: Eicosapntemacnioc acid MCTR: Maresin conjugate in tissue regeneration sEH: Soluble epoxide hydrolase 12-LOX: 12-Lipoxygenase LTC4S: Leukotriene C4 synthase GSTM4: Glutathione S-transferase MU 4 GGT: Gamma-glutamyltransferase DPEP: Dipeptidase NF-[kappa]B : Nuclear factor kappa B PDGF: Platelet-derived growth factor TGF-[beta]1: Transforming growth factor [beta]1 TRPV1: Transient receptor potential V1.
13S,14S-epoxy-maresin is also a substrate for glutathione S-transferase MU 4 (GSTM4) and leukotriene C4 synthase (LTC4S) yielding MCTR1, which is then converted to MCTR2 by gamma-glutamyl transferase (GGT) and to MCTR3 by dipeptidase (DPEP).
Soja et al., "Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma," The Journal of Clinical Investigation, vol.
Vila, "Leukotriene A4 hydrolase and leukotriene C4 synthase activities in human chondrocytes: transcellular biosynthesis of leukotrienes during granulocyte-chondrocyte interaction," Arthritis and Rheumatism, vol.
Steiner et al., "Association between a leukotriene C4 synthase gene promoter polymorphism and coronary artery calcium in young women: the Muscatine study," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma.
Nordestgaard, "Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals," Journal of Thrombosis and Haemostasis, vol.
Leukotriene C4 synthase (LTC4S) is an important enzyme involved in the production of cysLTs.