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References in periodicals archive ?
Partial association of restriction polymorphism of the ligand binding domain of human androgen receptor in prostate cancer.
The E/F domain or ligand binding domain (LBD) binds with specific small molecules which activates the receptors leading to the targeted sequential expression of genes.
Yasuda et al., "Different residues mediate recognition of 1-O-oleyl-lysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor," Journal of Biological Chemistry, vol.
The similarity of the ligand binding domain (LBD) is also high for PPAR[alpha] and PPAR[gamma] (cPPAR[alpha] versus hPPAR[alpha]: 96%; cPPAR[gamma] versus hPPAR[gamma]: 96%).
Further modifications to the bR ligand binding domain result in receptors with unique transactivational characteristics.
1998); these plasmids contain the yeast Gal4 DNA binding domain fused to the ligand binding domain of SXR or PXR.
In the presence of ligands, conformational changes of the ligand binding domain result in the recruitment of coactivator proteins, release of corepressor proteins, and subsequent assembly of a protein complex that enhances transcription of the target genes [28, 29].
Results from a binding assay using thioredoxin-fused AR ligand binding domain demonstrated that HCB did not influence binding of androgen to its receptor.
The direct transfer of the ligand through a transient protein-protein interaction with the ligand binding domain of the cognate PPAR would solve these issues.
Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function.