For the second half of FY19 the company expects to: establish scalability parameters of new, optimized manufacturing method for lipid nanoparticle
delivery system as part of new Genprex research and development program; complete protocol for Oncoprex + immunotherapy clinical trial; prepare and file IND for Oncoprex + immunotherapy clinical trial; and determine clinical site selection, expansion strategy and contract with clinical sites for Oncoprex + erlotinib clinical trial.
OncoSenX is developing a highly selective tumor-killing platform with two main components: a proprietary lipid nanoparticle
for cellular delivery and a highly selective DNA payload.
It includes two mRNAs that encode the heavy and light chains of this anti-Chikungunya antibody within Moderna's proprietary lipid nanoparticle
More specifically, Onpattro encases the siRNA into a lipid nanoparticle
to deliver the drug directly into the liver, in an infusion treatment, to alter or halt the production of disease-causing proteins.
delivery systems pose a feasible solution, as appropriately designed lipid-based vesicles have the potential for rapid uptake into circulation and greatly increased cellular delivery.
Muller-Goymann, "Effect of beeswax modification on the lipid matrix and solid lipid nanoparticle
crystallinity," Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol.
Solid Lipid Nanoparticles
. An unconventional carrier system, solid lipid nanoparticle
(SLN), was developed at the beginning of the 1990s, over the conventional lipoidal carriers like emulsions and liposomes.
Human SERPINA1 mRNA was observed in liver (Figure 3(a)) as may be expected given that the mRNA is encapsulated in a lipid nanoparticle
which generally delivers a large amount of its cargo to the liver.
Accordingly, it could be decided that CIP might be administered at longer time intervals by loading it in a solid lipid nanoparticle
Kim et al., "A retinyl palmitate-loaded solid lipid nanoparticle
system: Effect of surface modification with dicetyl phosphate on skin permeation in vitro and antiwrinkle effect in vivo," International Journal of Pharmaceutics, vol.
A single chain against prostate membrane antigen (PSMA) was conjugated to the copolymer, DSPE-PEG maleimide, that spontaneously assembled into a homogeneous multivalent lipid nanoparticle
 (Figure 1) and then was expressed and evaluated by [sup.64]Cu PET imaging in a prostate cancer xenograft model, and the results revealed that the targeted anti-PSMA scFv-LNP showed enhanced tumor accumulation, which may provide evidence for targeted therapy of this system in drug delivery.
TKM-130803, a small interfering RNA lipid nanoparticle
product, has been developed for the treatment of Ebola virus disease (EVD).