Particularly, in the last decade, association with lipids, usually referred to as lipid-based delivery systems, gained much interest as they are nontoxic, biodegradable, and highly biocompatible and show great versatility.
Likewise, it also summarizes the delivery systems currently used to enhance the clinical use of Phy by increasing their oral bioavailability and by promoting their safe and targeted activity, mainly emphasizing the lipid-based delivery systems.
Use of Lipid-Based Delivery Systems to Increase the Clinical Efficacy of Antitumor Phytochemicals Administered Orally
Furthermore, it is worth mentioning that, in recent years, an increased interest has been focused on the incorporation of poorly water-soluble compounds into lipid-based delivery systems (LBDS).
Formulation Approaches for Oral Lipid-Based Delivery Systems. LBDS can be obtained by blending excipients such as pure triglyceride oils, mixed glycerides, lipophilic surfactants, hydrophilic surfactants, and water-soluble cosolvents, which determine the absorption process .
Mode of Action of Oral Lipid-Based Delivery Systems. The goal of any oral LBDS is to enhance the GI absorption and oral bioavailability of the active compound.
(IV) In addition of increasing water solubility, absorption, and oral bioavailability, lipid-based delivery systems have been shown to
Types of the Main Oral Lipid-Based Delivery Systems and Their Applications
This need is reflected in the development of new delivery mechanisms, where lipid-based delivery systems are part of a strategy to increase the water solubility and stability, prevent the rapid systemic clearance, prevent the intestinal and hepatic metabolism, enhance the bioavailability, and enhance the cancer cell targeting.
Moreover, triglycerides have many advantages as the foundation of lipid-based delivery systems. They are commonly ingested in food, fully digested and absorbed, and therefore do not present any safety issues .
Porter, "Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies," Advanced Drug Delivery Reviews, vol.