McCuskey, "Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation," American Journal of Physiology--Gastrointestinal and Liver Physiology, vol.
Ayala, "Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1," Journal of Leukocyte Biology, vol.
Fibrosis is a chronic condition which initiates a cascade of biochemical and biophysical changes in the liver microenvironment causing necrosis and apoptosis of hepatocytes (highly specialized epithelial cells) and liver sinusoidal endothelial cells (LSECs), through the release of inflammatory mediators and profibrotic cytokines and activation of hepatic stellate cells.
The intricate network of capillaries of the liver is lined by liver sinusoidal endothelial cells (LSECs), a specialized endothelial cell type that is phenotypically different from vascular endothelial cells .
DeLeve, "Liver sinusoidal endothelial cells in hepatic fibrosis," Hepatology, vol.
Liver sinusoidal endothelial cells: physiology and role in liver diseases.
Acidosis protects against lethal oxidative injury of liver sinusoidal endothelial cells. Hepatology 2010; 14: 150-157, doi: 10.1002/hep.1840140125.
Gastrodin (GSTD) treatment reduced cell apoptosis and protected cell viability in [H.sub.2][O.sub.2]-exposed liver sinusoidal endothelial cells (LSECs).
Gastrodin (GSTD) treatment suppressed caspase-9 pathway and maintained high Bcl-2/Bax ratio in [H.sub.2][O.sub.2]-exposed liver sinusoidal endothelial cells (LSECs).
NLRP3 = nucleotide-binding and oligomerization domain (NOD), leucine-rich repeat and pyrin domain containing 3; LSECs = liver sinusoidal endothelial cells
; Ccl2 = monocyte chemoattractant protein-1 (MCP-1) gene; Pr[2x.sub.7] =purinergic receptor [2X.sub.7] gene; Nlrp3 = NLRP3 gene; Casp1= caspase-1 gene; Il1[beta] = interleukin-1fi gene; TNF-[alpha] = tumor necrosis factor-a; BzATP = 2(3)-O-(4- benzoylbenzoyl)ATP.