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LXRLiver X Receptor (molecular biology)
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References in periodicals archive ?
Alexar Therapeutics is aimed at developing a range of Liver X receptor agonists for both systemic and local use.
Baron, "Selective liver X receptor modulators (SLiMs): what use in human health?" Molecular and Cellular Endocrinology, vol.
Liao, "Selective activation of liver X receptor alpha by 6a-hydroxy bile acids and analogs," Steroids, vol.
Chen et al., "The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions," Molecular and Cellular Biology, vol.
Effects of activation of liver X receptor and peroxisome proliferator-activated receptor alpha on bile acid synthesis in rats.
Thus, RXR can form heterodimers with the liver X receptor (LXR), the farnesoid receptor (FXR), and the peroxisome proliferator activated-receptors (PPARs).
Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.
PGC1[alpha] is related to transcriptional factors such as PPAR[alpha], PPAR[gamma], estrogen-related receptor, liver X receptor, and hepatocyte nuclear factor-4[alpha].
To date, several transcriptional regulators of CD36 are reported, including ligandsensing and lipogenic transcriptional factors, such as cytosolic aryl hydrocarbon receptor (AhR), and several nuclear hormone receptors such as pregnane X receptor (PXR), liver X receptor (LXR), and PPAR[gamma] [25].
Gross et al., "Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor a in mouse liver reveals extensive sharing of binding sites," Molecular and Cellular Biology, vol.
CAR is a member of the NR1 subfamily; several other nuclear receptors such as pregnane X receptor; PPARa, p, y; liver X receptors a, p; and farnesoid X receptor a are also members of the NR1 subfamily and are related to the pathogenesis of NAFLD [14].
Published in the March issue of the journal Gastroenterology, the study shows that liver X receptors (LXRs), master regulators of cholesterol, fat, and inflammatory gene expression, also control the fibrosis-making cells of the liver, known as hepatic stellate cells.
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