They are based on LNA (Locked Nucleic Acid
MRG-110 is a locked nucleic acid
modified oligonucleotide inhibitor of microRNA-92.
Respected for his extensive RNA experience and involvement in the Locked Nucleic Acid
drug platform, Dr Bo Rode Hansen has authored and co-authored over 40 peer reviewed publications.
In addition to products spanning sample technologies, assay technologies and bioinformatics solutions, Exiqon brings to Qiagen a portfolio of proprietary technologies and know-how used in molecular testing, including relevant Locked Nucleic Acid
The contract has been signed for the expansion of rights to its Locked Nucleic Acid
Santaris' Locked Nucleic Acid
(LNA) platform is focused on the discovery and development of RNA-targeting therapeutics, a new class of medicines with the potential to address hard to treat diseases.
Scholtka and colleagues used 80 human colon tissue samples representing cancers and precancers to detect genetic variations using a combination of two techniques: The first technique - locked nucleic acid
(LNA)-based, wild-type blocking (WTB) polymerase chain reaction - suppressed normal DNA present in large quantities in the sample; and the second technique - high-resolution melting (HRM) - enhanced the detection of genetic variations.
Our results demonstrated that the addition of locked nucleic acid
hydrolysis probes specific for pandemic (H1N1) 2009 virus into previously established SYBR green assays can help differentiate segments of pandemic (H1N1) 2009, Eurasian avian-like, and triple reassortant virus lineages.
Separately, Shire has entered into a research-based collaboration with Santaris Pharma A/S, a leading player in RNA-based therapeutics, to develop its proprietary Locked Nucleic Acid
technology in a range of rare diseases.
24 August 2009 - Danish biotech company Santaris Pharma A/S said today that UK pharmaceutical company Shire Plc (LON: SHP) will use Santaris's locked nucleic acid
(LNA) drug platform to identify and select drug candidates for the treatment of rare genetic disorders.
Among the topics of individual chapters are discovery and development of RNAi therapeutics, locked nucleic acid
, morpholinos, applications for inflammatory diseases, and potential applications in ophthalmology.