L.T.P.

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L.T.P.Long-Term Potentiation
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Long-term potentiation (LTP) is a widely used paradigm for increasing synaptic efficacy, and the induction of one form of LTP requires the activation of NMDA receptors (Collingride and Daries, 1989).
Abbreviations NMJ: Neuromuscular junction EJCs: Excitatory junctional currents EPSCs: Excitatory postsynaptic currents PTP: Posttetanic potentiation LTP: Long-term potentiation Difopein: Dimeric fourteen-three-three peptide inhibitor FKO: Functional knockout PSD: Postsynaptic density LIMK: LIM kinases SSH: Slingshot.
Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1.
Long-term potentiation: outstanding questions and attempted synthesis.
Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture.
(15)-(17) Single spine long-term potentiation protocols have clearly revealed a strong correlation between the extent of potentiation of AMPA currents and that of spine head enlargement.
Additionally, in behaving animals, long-term potentiation is preferentially induced at the peak of local theta rhythm in hippocampi, and long-term depression is induced in response to stimulation at the trough.[30] Therefore, novel devices need to be developed to stimulate in a closed-loop pattern and controlled by behavioral feedback and brain signals.
It is also well established that learning and memory is a key function of hippocampus and one type of plasticity called as long-term potentiation takes place in this area of brain.
This process is called long-term potentiation (LTP).
Animals with AIE also manifested more robust long-term potentiation as adults when they were compared with nonexposed animals, a pattern of neurophysiological activation similar to the pattern normally seen in adolescents.
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