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LOPIDLicensed Operator Identification Code
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The most widely used fibrates in the United States are gemfibrozil (Lopid) and fenofibrate (Tricor).
These T2D patients were regularly treated with glycemic lowering drugs (glipizide, glibenclamide and/or metformin), lipid lowering drug (hydrochlorothiazine: HCTZ, or simvas or lopid), and anti-hypertensive drug (Atenolol and/or Enalapil).
(25,26,41-43) In fact, the concurrent use of gemfibrozil (Lopid), a fibric acid derivative, was associated with 1/3 of rhabdomyolysis related deaths in patients using cerivastatin.
Taking statins with niacin or fibric acids like gemfibrozil (Lopid) or fenofibrate (Tricor) may increase the risks of rhabdomyolysis.
Drugs commonly prescribed to reduce triglycerides include gemfibrozil (Lopid) and clofibrate (Abitrate).
Jones receives research support from Pfizer Inc., which markets gemfibrozil (Lopid), and from Abbott Laboratories, which markets fenofibrate (Tricor).
Fibrate medications, such as gemfibrozil (Lopid) and fenofibrate (TriCor), have shown similar efficacy in one trial, and niacin has been found effective in decreasing LDL/triglyceride levels and increasing HDL levels (Ginsberg, 2003).
Patients were randomly assigned (by chance, like flipping a coin) to receive gemfibrozil (Lopid), a drug used to treat dyslipidemia (37 patients); metformin (Glucophage), a drug used to treat insulin resistance (35 patients); or a placebo (36 patients).
According to the FDA, "Fatal rhabdomyolysis reports with Baycol have been reported most frequently when used at higher doses, when used in elderly patients, and particularly when used in combination with gemfibrozil (Lopid and generics)."
Hypolipidemic myopathy (meaning, in general, muscle aches and damage) is still a problem with the statins when used with the drugs Lopid, Tricor and Lipidil, and especially with niacin.