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References in periodicals archive ?
Likewise, there was no significant association between laboratories with false-negative results and the reported lower limit of detection based on allele fraction for SNVs, average coverage, or minimum coverage (Table 3).
Therefore, if the test is performed with a standard sample size of 0.1 ml, the smallest differentiating absorbance corresponds to 3.4 mg/L, and the recommended lower limit of detection is 6.8 mg/L using an absorbance difference of 0.02.
Biomarker Lower limit of Lower limit of detection (LOD) quantification (pg/mL) (LLOQ) (pg/mL) Eotaxin-1 1.863 2.9 Eotaxin-2 0.739 5.9 IFN-[gamma] 0.108 2.9 IL-1[beta] 0.404 2.9 IL-4 0.600 2.9 IL-6 0.683 1.5 IL-8 0.535 1.5 IL-10 0.503 2.9 IL-17 0.445 5.9 IL-23 0.612 5.9 IP-10 0.458 5.9 MCP-1 0.284 5.9 RAGE 0.968 5.9 TGF-[beta] 0.398 2.9 TNF-[alpha] 1.126 1.5 VEGF 0.744 1.5 The lower limit of detection (LOD) is the concentration of biomarker required to give a signal that is equal to the background (blank) plus three times the standard deviation of the blank.
The company said that all 14 patients in the trail were found to have circulating interferon Alpha-2b levels below the bioassay's lower limit of detection (6.25 pg/mL) at all sampling time points.
The new validation package enables users to test specifications including background noise, background spike, lower limit of detection, crosstalk, linearity, relative luminescence units (RLU), well-to-well precision, left-to-right bias, top-to-bottom bias, and kinetic noise, spike, and drift in the low and high signal ranges.
The lower limit of detection for the extraction method is approximately 25 ppb.
Guardant Health researchers demonstrated 95% analytical sensitivity for MSI-High status at variant levels below 0.4%, and a lower limit of detection of 0.1% using Guardant360.
Use of such reference materials has allowed documentation of the lower limit of detection for single variants ranging from <0.1% to >1%, depending on the assay.
Youden index and optimal cut-point estimated from observations affected by a lower limit of detection. BiomJ 2008; 50:419-30.
Unless the WBC count exceeds the lower limit of detection for the RBC count, any interference from the WBC would not be reported in the RBC count.
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