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Patient Reference Test result interval Lupus anticoagulant test DRVVT, seconds 65.5 33-44 DRVVT mix, seconds 63.2 33-44 DRVVT confirmation, screen/ 1.70 0.00-1.20 confirmation Prothrombin time, seconds 12.6 10.0-14.0 APTT, seconds 33.5 22.8-35.0 Thrombin time, seconds 15.9 14.0-21.0 APS antibody test Anticardiolipin antibody Negative Negative Anti-[beta]2 glycoprotein I Negative Negative antibody Autoimmune antibody panel Antinuclear antibody (ANA) Positive Negative Anti-dsDNA Positive Negative Antihistones Positive Negative Anti-Sm Positive Negative Anti-snRNP70 Positive Negative SS-A(Ro) Positive Negative SS-B(La) Negative Negative Anti-Scl-70 Negative Negative Anticentromere Negative Negative Jo-1 Negative Negative Table 2.
[11,12] Some studies have investigated the influence on mortality of the anticardiolipins and lupus anticoagulants. [3,11] In a study comparing patients with SLE-associated APS to those with primary APS, no difference was determined between two groups regarding mortality incidence.
Also, variable responsiveness of reagents used in INR test to lupus anticoagulant can complicate monitoring.
The laboratory criteria require a finding of lupus anticoagulant, mediumor high-titer (greater than 40 GPL) IgG or IgM anticardiolipin antibodies, and / or mediumor high-titer (greater than 40 GPL) anti-beta2-glycoprotein-1 antibody.
ENA (anti-Ro/SSA, anti-La/SSB, anti-Sm, anti-RNP), anticardiolipin (anti-CL, IgG, and IgM isotype), and anti-[beta]2-glycoprotein I (anti-[beta]2GPI, IgG, and IgM isotype) antibodies were performed by ELISA (Diamedix, Miami, FL, USA); lupus anticoagulant (LA) was assessed according to the guidelines of the International Society on Thrombosis and Hemostasis (Scientific Subcommittee on lupus anticoagulant/phospholipid-dependent antibodies) [11].
Yoshida, "Cross-mixing test to detect lupus anticoagulant for diagnosis of antiphospholipid syndrome," Rinsho Byori, vol.
This yielded a partial correction, suggesting the presence of an inhibitor such as lupus anticoagulant.
He had no evidence of infection, no heparin use, no lupus anticoagulant, and no serum cryoglobins.
The most clinically important APLs are the lupus anticoagulant, the anticardiolipin antibodies, and anti-[beta]2 GPI.
This is diagnosed by performing a blood test for two antibodies; the anticardiolipin antibody and the lupus anticoagulant. Blood tests may also be performed to assess blood clots, known as a thrombophilia, screen.