Any heart with a HR < 250 beats/min, CF > 18 mL/min or < 8 mL/min, or LVDP
< 80 mmHg when the LVEDP was maintained at 5-10 mmHg at the end of stabilization was excluded from the study.
IR significantly deteriorated cardiac function as demonstrated by significantly decreased CF, LVDP
, [+ or -][d.
Furthermore, experimental hypertension is associated with higher infarct size and probability of arrhythmia following ischemia reperfusion, (9) decreased recovery of LVDP
, (8) and higher coronary resistance.
However, hearts from the multipollutant-mixture group had lower baseline LVDP
Thus, the decrease in LVDP
may be responsible for the decrease in coronary flow.
For the ischaemic control group, the end of the reperfusion was marked by a dramatic decrease of LVDP
, HR and coronary flow compared with the pre-ischaemic values (Table 1).
female's hearts displayed better recovery of LVDP
than the hearts
In CI/R group, compared with baseline, LVDP
, [+ or -]dp/[dt.
Compared with S group, the other groups had a significant decrease in HR, LVDP
and dp/dtmax, an great increase ( P < 0.
was decreased seven fold by the adriamycin administration compared to the CONT (p<0.
After ischemia reperfusion, the FR ultra-fine group showed significantly lower recovery of postischemic LVDP
(Figure 6A) and increased infarct size (Figure 6B) compared with the saline controls.
The CF and LVDP
were continuously monitored during the perfusion of modified Krebs buffer in COC extract-treated heart and I/R heart.