(13,120) In contrast to VI, the role of lymphatic invasion
(also called small vessel invasion) as an independent prognostic indicator is uncertain at this point, and the RCPath(UK) still considers the evidence insufficient for the inclusion of lymphatic invasion
as a mandatory data element.
It was also found that the positive expression of CD44v6 was related to lymph node metastasis and lymphatic invasion
in early gastric cancer, which indicated that CD44v6 might be involved in the lymph node metastasis of early gastric cancer.
The aim of this study was to compare the results of detecting lymphatic invasion
in immunohistochemistry (IHC) method with routine histologic evaluation.
[33,34] In this study histological grade of triplenegative cancer was similar with non-triple-negative cancer, but the rate of the people who had the family history of breast cancer, the rate of lymphatic invasion
and larger tumour size (more than 5 centimetres) in triple-negative cancer was higher than that of in non-triple-negative cancer that was statistically significant.
On univariable analysis, younger age ([less than or equal to]60 years), higher tumour grade, vascular invasion, lymphatic invasion
, pathologic T stage, SCC variants (basaloid/spindle) and tumour size>3cm were found to be significant predictors for the presence of LN metastases (Table 2).
The degree of lymphatic invasion
, venous invasion, perineural invasion, pancreatic invasion, and duodenal invasion was classified in detail as follows: ly0, v0, pn0, panc0, and du0 = no evidence of invasion; ly1, v1, pn1, panc1, and du1 = mild invasion; ly2, v2, pn2, panc2, and du2 = moderate invasion; and ly3, v3, pn3, panc3, and du3 = severe invasion, respectively .
Moreover, there were both microvessel and lymphatic invasion
, as well as renal sinus and perinephric fat invasion in the kidney.
Assessment of lymphatic invasion
in the primary tumor was in 34 (65.38%) cases of G1 and in 10 (25%) cases of G2.
We also evaluated the following clinical and histological parameters of the cancer: age at diagnosis, ethnicity, family history of DTC, smoking history, follow-up time, presence of thyroid antibodies, size and number of malignant nodules, histology type and variant, vascular and lymphatic invasion
, extracapsular or extrathyroidal invasion, histological differentiation grade, metastasis to lymph nodes and to distant organs, and tumor staging according to the tumor node and metastasis system (TNM) .
was subdivided by RS as follows: 24.1%, 18.9%, and 22.8%.
 supported the theory of metastasis through blood vessels due to the lack of lymphatic connection between colon and ovary, but Samanth and Black 3rd  and Lemming  have supported a lymphatic metastasis theory because of the pathological features of colon cancer lymphatic invasion
in cases with ovarian metastasis.
showed that lymphatic invasion
showed a strong association with lymph node metastasis and an increased risk of death .