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References in periodicals archive ?
Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation.
The preliminary data strongly suggest that lysyl oxidase inhibition alters the collagen architecture and restores it to the normal architecture found in the skin," Iyer says.
1999), causes stabilization of fibrinogen and up-regulation of copper-dependant enzymes, such as lysyl oxidase, important for matrix remodelling (Kobayashi et al.
Copper is also required for the activity of lysyl oxidase, an enzyme required for the cross-linking of collagen and elastin.
Some of the mechanisms responsible for this reduction are increased elastase activity,6 decreased serum elastase inhibitor level, decreased elastin gene expression, abnormal copper metabolism/copper deficiency and low lysyl oxidase activity.
For example, expression of the hypoxia-regulated gene LOX (lysyl oxidase) predicts relapse in human breast tumors (28), but recent studies suggest that systemic secretion of lysyl oxidase into the lung and liver might facilitate the homing of disseminated cancer cells to these organs through the formation of a prometastatic microenvironment (29).
The enzyme called lysyl oxidase (LOX) has been found to stiffen collagen, a major component of the supportive tissue in the breast.
Copper deficiency decreases the activity of lysyl oxidase and impairs the cross-linking of collagen in bone of experimental animals.
Through a molecular approach called differential display analysis, Hendrix's team identified the gene lysyl oxidase and a zinc finger transcription factor in highly aggressive breast cancer cells that spread.
A collagen-specific enzyme, lysyl oxidase, crosslinks these trimers into fibrils or meshworks.