M184V

AcronymDefinition
M184VReplacement of Methionine 184 with Valine (virology)
References in periodicals archive ?
Most commonly, lamivudine monotherapy is used as a holding regimen in children with known lamivudine resistance, on the premise that the lamivudine-associated M184V mutation reduces viral replication.
The genotyping for drug resistance showed no PI mutations, but reverse transcriptase (RT) mutations included K103N, V179E, M184V and T2151T.
A repeat genotype and initial PhenoSense performed at this time revealed he had developed a M184V mutation in addition to the K103N and he had reduced elvitegravir/raltegraver susceptibility.
Lamivudin (3TC) iceren tedavi rejimleri ile basarili sonuclar saglanmakla birlikte, tek pozisyonda M184V gibi mutasyonlar; ilaca karsi duyarliligin 100-1000 kat arasinda azalmasina neden olmaktadir (5).
However, neither the K103N nor the M184V mutation was detected in any of those 222 clones, but both mutations were rapidly selected during early treatment failure.
However, an unexpected activity of ETV against HIV was reported in 2007, with demonstration of ~1 [log.sub.10] decline in plasma HIV-RNA and selection of M184V in HIV [33].
M184V by itself causes high-level (>100-fold) resistance to lamivudine and emtricitabine.
The patients had a mean baseline viral load of 31,600 copies/mL and most had NRTI-associated mutations: 60% had the M184V mutation, 66% had M41L, 50% had four to six thymidine analogue mutations, and 6% had K65R.
Reverset was also shown to be effective in patients with virus resistant to other commonly used nucleoside analog reverse transcriptase inhibitors (NRTIs), including viruses harboring multiple thymidine analog mutations (TAMS), including the M41L and L210W mutations, and the L74V and M184V mutations.
The patients had a mean baseline viral load of 31,600 copies/mL and the majority had NRTI-associated mutations: 60% had the M184V mutation, 66% had M41L, 50% had four to six thymidine analogue mutations, and 6% had K65R.
La mutacion M184V asociada con la resistencia a la lamivudina se relaciono con un aumento de la respuesta virologica 35.