A study in mice genetically lacking ABCC3 revealed that this transporter is involved in the efflux of M3G and M6G from the liver to the bloodstream (37).
 Nonstandard abbreviations: PK, pharmacokinetic; PGx, pharmacogenetics; MAF, minor allele frequency; UM, ultrarapid metabolizer; EM, extensive metabolizer; IM, intermediate metabolizer; PM, poor metabolizer; PD, pharmacodynamic; PCR_RFLP, PCR-restriction fragment length polymorphism; CE-IVD, European Conformity-In Vitro Diagnostic Medical Devices; M3G, morphine-3-glucuronide; M6G, morphine-6-glucuronide; SNP, single nucleotide polymorphism; AUC, area under the concentration curve; MOR, popioid receptor.
The six common anthocyanins are D3G, Pt3G, C3G, M3G, P3G, and Pa3G; their compounds and structures can be obtained from Pubchem .
Taking an analysis of clustering, the structures become stable in order of speed: C3G > (unbound protein) > Pt3G > Pa3G > D3G > FK506 > P3G > M3G.
In the first study, morphine and the major morphine metabolite, morphine-3-glucuronide (M3G), were spiked into morphine and 6AM-negative urine samples (n = 3) to create 2 sets of samples: 5 concentrations of morphine samples (10 000, 50 000, 100 000, 150 000, and 200 000 [micro]g/L) in 1 set and 5 concentrations of M3G samples (16 250, 81 250, 162 500, 243 750, and 325 000 [micro]g/L) in the other set.
After incubation for 18 h using [beta]-glucuronidase in acetate buffer, all urine samples with increased morphine (>100 000 [micro]g/L) and 78% of the samples with increased M3G (> 162 500 [micro]g/L) formed measurable 6 AM ([greater than or equal to] 5 [micro]g/L).
(NASDAQ:ADSK), has formed a partnership with Criterion Software, a provider of middleware solutions for the game development industry, to provide support for JSR-184 (M3G
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Under the dissection microscope (Wild M3G
; Leica), the pulmonary artery was cleared of adjacent tissue and cut into small segments (2-3 mm).