ELS-induced, long-term disruption of HPA axis function and epigenetic regulation of genes such as NR3C1 and FKBP5, in turn, can affect epigenetic regulation of the BDNF, TH, and MAOA
Family-based association studies support a sexually dimorphic effect of COMT and MAOA
on genetic susceptibility to obsessive-compulsive disorder.
Finally, the genes related to the inactivation of 5-HT present low expression of the gene that codes for the expression of MAOA
is seen in all structures, while the gene that codes for the monoamine oxidase enzyme MAOB has medium expression in the thalamus and low expression in the hypothalamus, midbrain, and pons (Figure 2 Supplementary).
Taylor et al., "MAOA
, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis," Molecular Psychiatry, vol.
This indicates that many targets are hit by multiple compounds, but some can be modulated by only one compound (peripheral nodes, such as MAOA
, LYZ, and IMPA).
of Cincinnati), available at https://www.ncjrs.gov/pdffilesl/nij/grants/231609.pdf (A 430 page dissertation funded by an NIJ grant and published through a link available on the NIJ website that provides a comprehensive analysis of the correlations between dopamine function, serotonin function, and MAOA
variant status on levels of aggression, delinquency, substance abuse, arrest, and commission of crimes); See also Wolfgang et al., supra note 230 (providing an overview of historical research funded by NIJ).
A study analyzed the DNA of almost 900 offenders in Finland and found those with MAOA
gene, referred to as the warrior gene, and a variant of cadherin 13 (CDH13) were 13 times more likely to have a history of violent behavior.
If you have a short version of the MAOA
gene you are about 85 per cent more likely to be aggressive throughout your life."
The effect of smoking on MAOA
promoter methylation in DNA prepared from lymphoblasts and whole blood.
Aunado a ello, la degradacion de la dopamina por la MAOA
produce especies reactivas de oxigeno (ROS) que afectan a la cadena respiratoria mitocondrial y generan un circulo vicioso, al reducir la produccion de ATP (56,57).
Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA
Focusing much of the book on the subject of the MAOA
or aecriminal gene,AE Wilson aims to provide the basis for a much-needed discussion on the increasing use of genetic information during police investigations and criminal proceedings by considering how judges and juries have responded to legal arguments based on this emerging scientific understanding.