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MAP1BMicrotubule-Associated Protein 1B
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These subgroups were characterized by divergent expression of, e.g., EMT-associated genes (CDH2, COL1A2, COL5A2, FN1, MAP1B, MMP3, SOX10, SPP1, ZEB1, and ZEB2), DNA repair genes (RAD51) (21) or targets relevant for cancer therapy.
JNK exerts its effects on the cytoskeleton by phosphorylating numerous microtubule-associated proteins (MAPs) such as MAP2, MAP1B, tau and the stathmin family microtubule-destabilizing protein SCG10.
Microtubule-associated protein 1B (MAP1B) is made up of a heavy chain and a light chain (LC1) and has an important role in the stability of the cytoskeleton.
Hyperphosphorylated tau sequesters normal tau and other neuronal microtubule associated proteins (MAPs), such as MAP1A, MAP1B, and MAP2, contributing further to disassembled microtubules, disruption of the axonal cytoskeleton, and transport, culminating as damaged neurons [52].