MAP3KMitogen-Activated Protein Kinase Kinase Kinase
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26,27) Mammals also express ASK2, which is another MAP3K highly homologous to ASK1.
21) Thus far, MAP3K kinases (MAP4Ks) that directly activate ASK1 by phosphorylating Thr838 of ASK1 have not been identified.
Recently, exome sequencing of metastatic melanoma cells reveals somatic mutations in the genes encoding ASK1 and another MAP3K, mixed lineage kinase 1 (MLK1).