MAPEGMembrane-Associated Proteins in Eicosanoid and Glutathione
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of Molecular localization amino acid weight residues (kDa) PGES mPGES-1 9q34.11 152 16 mPGES-2 9q34.11 377 33 cPGES 12q13.3 160 23 PGDS H-PGDS 4q22.3 199 23 L-PGDS 9q34.3 190 26 PGIS PGIS 20q13.13 500 56 TXS TXS 7q34 533 60 Structural Tissue characteristics distribution PGES mPGES-1 MAPEG family Inflamed tissues, cancerous tissues, kidney mPGES-2 Glutaredoxin/ Almost all tissues thioredoxin-like cPGES -- Almost all tissues PGDS H-PGDS Glutathione-S- Mast cells, transferase microglia, Th2 cells, etc.
All classes of MAPEG were mainly expressed in brain, heart, spleen, kidney, intestine and liver.
Previous reports have described 9 classes of carp GST genes from three GST subfamilies: MAPEGs (mGST1, mGST2 and mGST3), Kappa from the mitochondrial GSTs, and the cytosolic GSTs (Mu, Alpha, Theta, Pi and the Rho which is special in fish and shares no molecular homologue in mammals) (Konishi et al., 2005; Fu and Xie, 2006).
Most GST proteins include 200 to 250 amino acids except for MAPEGs (MGST1.1a, MGST1.1b, MGST1.2, MGST2, MGST3.1, MGST3.2) which are much shorter.
For example, GSTK exhibited a closer evolutionary relationship with members of MAPEGs than other classes of GSTs, whereas sequence structures showed great differences.
In plants, there are also reports from the other GST subfamilies, like microsomal GSTs which are members of the MAPEG (membrane-associated proteins in eicosanoid and glutathione metabolism) family (Diesperger & Sandermann, 1979; Zettl et al., 1994) and apoplast-localized enzymes (Flury et al., 1996).