The MAPHY study demonstrated the significantly lower risk for coronary events in patients on metoprolol, a lipophilic beta-blocker, as compared to those on diuretics .
Tuomilehto et al., "Metoprolol versus thiazide diuretics in hypertension: morbidity results from the MAPHY study," Hypertension, vol.
In the 1980s, numerous trials were developed to address the question: "What is the best way to treat high BP?" These included the Heart Attack Primary Prevention in Hypertension (HAPPILY) trial, (7) the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY
) study, (8-10) the Treatment of Mild Hypertension Study (TOMHS), (14) and the VA Cooperative Study on single drug therapy.