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Related to MAPK: MEK, PI3K
MAPKMitogen-Activated Protein Kinase
MAPKMicrotubule-Associated Protein Kinase
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An important factor in determining the biological consequences of p38[delta] MAPK phosphorylation is the strength and duration of the activation signal.
Primers for p38 MAPK target genes and the internal control GAPDH were synthesized by Shanghai DaWeiKe Biotechnology.
MEK proteins occupy a pivotal position in the MAPK pathway, a key signaling network that regulates cell growth and survival, and that plays a central role in multiple oncology and rare disease indications.
The protein expressions of phospho-p38 MAPK (pp.38 MAPK) and proliferating cell nuclear antigen (PCNA) in the VSMCs were subjected by Western blot.
To clarify whether GLCCI1 involved in the p38 MAPK pathway, we evaluated the phosphorylation ratio of the p38.
Although the MAPK Erk1/2 pathway is well known for regulating skeletogenesis, the in vivo physiological role of the Mek5/Erk5 pathway in skeletal development has been largely unclear to date, because of the early embryonic lethality of global Erk5 knockout mice.
Antibodies were obtained from Cell Signaling Technology (Danvers, MA) unless otherwise stated: p38 MAPK antibody, phospho-p38 MAPK antibody, JNK1/2/3 antibody (Huaxingbio, Beijing, China), phospho-SAPK/JNK antibody, p44/42 MAPK antibody, phospho-p44/42 MAPK antibody, [beta]-actin antibody, anti-rabbit IgG, HRP-linked antibody.
To this end, we found that GA suppresses mitochondrial ROS via an anion carrier protein, uncoupling protein-2 (UCP-2), and through the effects of GA on the activation of MAPK.
showed that fucosterol inhibited the expression of inducible nitric oxide synthase, TNF-[alpha], and IL-6, as well as suppressed the NF-[kappa]B and P38 MAPK pathways in LPS-induced RAW264.7 macrophages [16].
Among these, the mitogen-activated protein kinase (MAPK) signaling pathway has been widely researched [9,10] and has been confirmed to regulate microtubules and actin filaments; the latter of which can produce pushing (protrusive) forces or pulling (contractile) forces that are particularly important for whole-cell migration [11-13].