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MAPK1Mitogen Activated Protein Kinase 1
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For example, deregulation of targetable tyrosine kinases was found in BCRABL1-like B-ALL96; deletions, amplifications, and/or mutations in NF1, NRAS, KRAS, MAPK1, FLT3, and PTPN11 were detected in hypodiploid B-ALL (97); NOTCH1/FBXW7 mutations were associated with T-ALL (98); genetic lesions in DNMT3A, FLT3, or NOTCH1 may play a role in adult early T-cell precursor ALL (99); and recurrent mutations in chronic lymphocytic leukemia/small lymphocytic lymphoma, MCL, marginal zone lymphoma, DLBCL, and multiple myeloma may have diagnostic and/or prognostic utility in selected patients.
MAPK1 is one of the final steps in the MAP kinase signaling pathway - a network of interconnected genes that play a role in cell growth regulation.