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MAPK1Mitogen Activated Protein Kinase 1
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Genes AKT1, BAD, BAX, BCL2, CASP3, CASP8, CASP9, MYC, PIK3CD, MAPK1, MAPK10, and CYCS are commonly expressed in the cluster of colorectal cancer, neuronal signaling pathway, neuronal death, amytrophic lateral aclerosis, and tuberculosis [51].
miR-335-5p is able to downregulate MAPK1 (mitogen-activated protein kinase 1) messenger translation.
There were also differences between the groups regarding genes related to cell proliferation, with higher relative abundance in the 5% [O.sub.2] group of HSF1, EGFR, and GSK3A, while MAPK1 was downregulated in this group and PLAC8 was only detected in the 20% [O.sub.2] group.
Among the enriched targets that are more strongly associated with cancer (i.e., RAP1B, N4BP1, MAPK1, and E2F6), almost all are protumoral.
DSW 600 downregulated expression of apoptosis inhibitor 5 BCL2- associated athanogene (Api5), cell death- inducing DFFA-like effector b (Ciedb), cytochrome c, and somatic (Cycs), Fas (TNF receptor superfamily, member 6), growth arrest and mitogen activated protein kinase 1 (Mapk1), PYD and CARD domain containing (Pycard).
miR-378 may promote bovine adipogenesis in white adipose tissue through targeting MAPK1 and PPARy [10].
The connectivity degree of certain genes exceeded 20, including DHX15, NDUFS3, PSMC6, UBE2C, EIF4G1, DHX9, PSMC3, and HNRNPA2B1 in the upregulated PPI network, and MAPK1, IL6, FN1, MAPK14, STAT3, and VWF in the downregulated PPI network (Table 1).
Many other genes are commonly mutated in CLL, including the following: NOTCH1; XPO1 (exportin 1); MYD88; KLH6 (Kelch-like 6); TP53; TGM; BIRC3; PLEKHG5; ATM; SF3B1 (splicing factor 3, B1 unit); ZMYM3; MAPK1; FBXW7; and DDX3X.
They include extracellular signal-regulated kinase (ERK)-I and -2, p38 kinases, ERK5 (big MAPK1) and c-Jun N-terminal kinases (JNKs) (Liu et al., 2000; Kyriakis et al., 1994).
Furthermore, FOXO3A is inactivated, and its target genes are downregulated, following phosphorylation by oncogenic kinases such as AKT, MAPK1, and IKK, which are upregulated in many tumors [17-19].