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MAPK13Mitogen Activated Protein Kinase 13
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Three culprits that form a molecular pathway emerged: MAPK13, an enzyme that gives an extra boost to a signaling molecule called CLCA1, which in turn enables a protein called IL-13 to activate the major mucus-producing gene in airway cells.
At the time, no drugs existed that could act against MAPK13, but several were able to inhibit a similar enzyme, MAPK14.
33,34,44) It was recently suggested that DNA methylation at 3 specific loci, TMEM30B, KAZALD1, and MAPK13, could be useful in the differential diagnosis of MPM.