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MAPK8Mitogen Activated Protein Kinase 8
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PGF and its downstream MAPK8 and MAPK14 signaling pathways are potential therapeutic targets for the treatment of emphysema and chronic obstructive pulmonary disease (COPD) [67].
Overall, these studies show that genes related to innate immune signaling-in particular TNF receptors 1/2 and toll-like receptors 2/4--may modulate risk related to [O.sub.3] exposure, as well as associated genes including Nfkb1 (nuclear factor of kappa light polypeptide gene enhancer in B cells 1), Jnk1 (mitogen-activated protein kinase 8; Mapk8), Cd44 (Cd44 antigen), Myd88 (myeloid differentiation primary response gene 88), Iai (inter-[alpha]-trypsin inhibitor), Hsp70 (heat shock protein 70), Mmp9 (matrix metallopeptidase 9), and Nos2 (nitric oxide synthase 2, inducible) (Bauer et al.
We found upregulated ERO1L and ITGA3 and downregulated PLAA ranked in the first class close to LOXL2-e13-DEGs and upregulated MAPK8 ranked in the second class.
Meanwhile, MAPK signaling pathway molecules including MEKK1, ASK1 (MAP3K5), MLK2 (MAP3K10), MLK3, NIK, MEK1 (MAP2K1), MEK2 (MAP2K2), MEK4 (MAP2K4), MEK7 (MAP2K7), ERK1 (MAPK3), JNK1 (MAPK8) and JNK2 (MAPK9) were significantly up-regulated and revealed 2.00-4.09 fold increases in expression level (Table 1).