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MAdCAM-1Mucosal Addressin Cell Adhesion Molecule 1
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With regard to the CCL20, CCR6, and MAdCAM-1 gene expression profiles, D-FL is similar to MALT lymphoma, and it was hypothesized that increased expression of CCL20 and MAdCAM-1, along with coexpression of CCL20 and CCR6, might play an important role in tumorigenesis.
MAdCAM-1 is preferentially expressed on blood vessels and lymph nodes of the gastrointestinal tract.
[4] Human genes: FN14, tumor necrosis factor receptor superfamily member 12A; TFPI, tissue factor pathway inhibitor; IL1RL1, interleukin 1 receptor like 1; MAdCAM-1, mucosal addressin cell adhesion molecule 1; CKm, creatine kinase, M-type.
One is mediated by the interaction between lymphocyte L-selectin and HEV-expressed sialomucins/PNAds, which is mainly used by naive lymphocytes, and the other is mediated by the interaction between lymphocyte integrin [alpha]4[beta]7 and the vascular cell adhesion molecule MAdCAM-1, which is mainly used by lymphocytes that have been exposed to antigen-experienced DCs in the small intestine.
Slides were then incubated for 60 minutes with the mouse monoclonal antibody [CD68.sup.+] (AbD Serotec, UK), the mouse monoclonal antibody [CD4.sup.+] (Thermo Scientific Inc., Germany), the mouse monoclonal antibody [CD8.sup.+] (Thermo Scientific Inc., Germany), the rabbit polyclonal antibody MAdCAM-1 (Biorbyt, UK), the rabbit polyclonal antibody IL-6 (Santa Cruz Biotechnology Inc., USA), the mouse monoclonal antibody TNF[alpha] (Acris Antibodies Inc., USA), or the mouse monoclonal antibody NF[kappa]B (Santa Cruz Biotechnology Inc., USA), or at 1:100, 1:150, 1:150, 1:250, 1:500, 1 : 500, or 1 : 500 dilutions, respectively.
-- Adhesion PECAM-1 CD31 -- molecules Protein Name * Receptor Ligands family location [alpha]4 NK VCAM-1 fibronectin NK VCAM-1 MadCAM-1 [alpha]6 NK Laminin Integrins [alpha]h, LFA-1 NK ICAM-1 ICAM-2 [alpha]M, Mac-1 NK ICAM-3 RAGE [beta]1 See above See above [beta]2 See above VLA-4 See above fIntegrin VLA-6 See above dimers LPAM-1 See above PSGL-1 E-selectin pECs sialyl LewisX Sialophoryn Mucosialin Selectins L-selectin NK MadCAM-1 GlyCAM-1 P-selectin pECs PSGL-1 Sialyl LewisX pMIC2?
Sialyl Lewis X-PNAd in L-selectin (CD62L) GlyCAM-1 (glycosylation- dependent cell adhesion molecule-1), CD34, and MadCAM-1 (mucosal vascular address in cell adhesion molecule 1) present in endothelium [57].
Se ha demostrado en ratones que el acido retinoico (obtenido del metabolismo de la vitamina A a nivel de la mucosa intestinal) estimula la expresion de los receptores homing ([alfa]4[beta]7 y ccr9) en las celulas T, los que se unen a sus ligandos (MadCAM-1 y CCL25) expresados por las venulas poscapilares del intestino, esenciales para direccionar el trafico linfocitario hacia la mucosa intestinal.
Masumoto et al., "GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity of ulcerative colitis," Inflammatory Bowel Diseases, vol.
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) is preferentially expressed on the endothelial lining of blood vessels in the lymphoid tissue of the bowel.
The ligand MAdCAM-1 is constitutively expressed by the mucosal endothelium in the small intestine and colon [32].
Effector T-cells migrating to intestinal sites express high levels of gut-homing molecule [alpha]4[beta]7 [27], with its ligand MAdCAM-1 being constitutively expressed by post-capillary endothelial cells in the small intestine [28] and colonic lamina propria [29].