There have been several different proteins that have been identified for their roles in the transcription repression (MBD1, MBD2
, MBD3, and MeCP2) (Wade, 2001).
DNA methylation is one of the most important epigenetic changes; it is catalyzed by DNA methyltransferase (DNMT) enzymes and takes place with the help of proteins that bind methyl-CpG (MBD1, MBD2
, MeCP2, etc.).
protein level in cervical cancer was relatively lower than normal cervical tissue (t = 4.11, P = 0.006).
Ou et al., "Global DNA methylation, DNMT1, and MBD2
in patients with rheumatoid arthritis," Immunology Letters, vol.
Han et al., "Mbd2
promotes foxp3 demethylation and T-regulatory-cell function," Molecular and Cellular Biology, vol.
Fox et al., "Decreased levels of mir-224 and the passenger strand of miR-221 increase MBD2
, suppressing maspin and promoting colorectal tumor growth and metastasis in mice," Gastroenterology, vol.
McQueen et al., "MBD1, MBD2
and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers," Oncogene, vol.
Global DNA methylation, DNMT1, and MBD2
in patients with systemic lupus erythematosus.
RESEARCH into a gene called MBD2
could lead to new treatments for colon cancer, after experts discovered that switching it off prevents tumours from forming.
In addition to finding that DNA methylation is a mechanism of latency, the scientists also discovered that a host protein, called methlyl-CpG binding domain protein 2 (MBD2
) binds to the methylated HIV DNA and is an important mediator of latency.
The Microtech MBD2
beam delivery system is designed for UV excimer lasers.
Researchers in Edinburgh hope their discovery of the MBD2
gene may help eliminate the need for painful chemotherapy treatments.