Vega et al., "Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles," Circulation Research, vol.
The endogenous regulatory protein RCAN1 (also known as MCIP1), which was mentioned earlier for its role in the regulation of Cn in brain, is envisaged to be important in the heart, because it not only enables the onset of but also bridles the hypertrophic response, depending on the nature of the hypertrophic stimulus (68, 69).