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MCM5Minimum Control Measure 5
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In addition, overexpression of MCM5, identified here as associated with maternal toenail arsenic levels, has previously been identified in a variety of human cancers (Gakiopoulou et al.
This PCR amplification was performed on replicate samples of MCM2, MCM5, and MCM8; results of next-generation sequencing are shown in Table 3.
Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine.
Positional cloning of mutated MCM5 in embryonic cells of Zebra fish leads to impaired retinal development characterized by deregulated cell cycle and increased rate of apoptosis.
Vitality and proliferative rate acquired by donor cells in vivo were further assessed by costaining cells for eGFP and MCM5 (Figures 5(d)-5(f)), a protein involved in the control of DNA replication.
Notably, genes required for G1/S transition were overrepresented in our array data, including CDKN1A, CCND1, CDK2, CDK4, MCM5, CDC2, CDC25A, and CDC25C (Figure 3) suggesting a cell cycle arrest in the G0/G1 phase.
Otros modelos de proteinas MCM (MCM2 y MCM5) han sido utilizados como factores de valor pronostico en el cancer cervical, 56) y en realidad se sabe que casi todos los genes MCM pueden inducir los factores de transcripcion E2F (57).
Research by Cancer Research UK found that high levels of a protein called Mcm5 in urine indicate the presence of cancer cells.
Candidate biomarkers include other cytokeratins (25); other nuclear matrix proteins, such as BLCA4 (26); other molecules, such as survivin (27), cyclooxygenase-2 (28), and Mcm5 (29); or the use of highly sensitive and specific techniques such as microsatellite analysis (17) or dual parametric flow cytometry (30).
Kai Stoeber, who was with the University of Cambridge at the time of the study, and his colleagues stated that although it is too early to say definitively what role their Mcm5 urine test might have in diagnosing bladder cancer, their findings show it is "highly predictive" of the disease.