MCP-1


Also found in: Medical.
AcronymDefinition
MCP-1Monocyte Chemoattractant Protein-1
MCP-1Monocyte Chemotactic Protein-1
MCP-1Macrophage/Monocyte Chemoattractant Protein-1 (immunology)
References in periodicals archive ?
Louis, MO, USA); CCK-8 ELISA kit was purchased from Beyotime Biotechnology (Shanghai, China); Annexin VAPC/7-AAD kit was purchased from BioLegend (San Diego, CA, USA); TNF-[alpha] and IL-1[beta] ELISA kit were purchased from R&D system (Minneapolis MN, USA); MCP-1 antibody was purchased from BioLegend (San Diego, CA, USA); the design and synthesis of MCP-1 mRNA primer were by Invitrogen (Carlsbad, CA, USA); RNA and RNAase H-reverse transcriptase were purchased from Invitrogen (Carlsbad, CA, USA); and RS102895 was purchased from Santa Cruz Biotechnology, Inc.
Among these, MCP-1 is one of the crucial adipocytokines, which accelerates macrophage infiltration into adipose tissue via the MCP-1 receptor, a CC chemokine receptor-2, and induces chronic low-grade inflammation [6, 7].
Latest literature reported that TLR9 gene knockout mice with a high-fat diet had more visceral fat accumulation and released inflammatory factors, such as IL-6, MCP-1 and TNF-[alpha] [9].
Previous studies demonstrated some association between cytokines IL-1[beta], TNF-[alpha] and MCP-1 and schizophrenia, however, few studies have focused on predicting response to antipsychotics by testing peripheral blood cytokines.
However, neither MCP-1, MCSF, nor neopterin has been tested, in the light of fractional excretion, as potential markers of tubular damage in the course of chronic kidney disease.
In this study, our aim was to assess whether there were genetically driven differences between the immune responses of healthy people and those with PD, specifically in terms of polymorphisms in chemokines and their receptor genes IL-8, MCP-1, RANTES, CCR2, and CCR5.
Previously, we reported that the expression levels of inflammation-related chemokines associated with MCP-1 were enhanced by stimulation with IL-1[beta] and/or IL-6/sIL-6R in gingival fibroblasts [39].
Fasting blood was collected for the determination of serum creatinine, CRP, and the concentration of MCP-1. Peripheral blood leukocyte count was performed (WBC).
Conclusion: AS attenuated progression of atherosclerosis lesion formation alone or combined with rosuvastatin through anti-inflammatory effect, resulting in down-regulation of TNF-[alpha] and IL-6, and further down-regulating IL-8 and MCP-1 expressions in aorta of WD fed [ApoE.sup.-/-] mice.
Monocyte chemoattractant protein-1 (MCP-1) facilitates the migration of inflammatory cells by chemotaxis and is the trigger signal of inflammation in atherosclerosis.[sup][1],[2] Adipocyte and adipose tissue not only play a role in lipid synthesis and storage, but also are associated with a low-grade chronic inflammation, supporting the notion that obesity plays an important role in the development of atherosclerosis as well as insulin resistance.
Differences in the intensity of MCP-1 staining were determined semiquantitatively and expressed as low, moderate, or high.